BimS, EL, L (AA 20-40) anticorps

N° du produit ABIN2745516

L’anticorps Rat Monoclonal anti- a été validé pour FACS, IP, IHC, WB, ICC et ELISA. Il convient pour détecter dans des échantillons de Souris, Chien, Humain, Singe et Rat.

Aperçu rapide pour BimS, EL, L (AA 20-40) anticorps (ABIN2745516)

Antigène: BimS, EL, L

Reactivité: Souris, Chien, Humain, Singe, Rat

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), ELISA

Clone: 3C5

Détail du produit

Épitope: AA 20-40

Specificité: Recognizes an epitope within aa 20-40 of human, mouse, rat, monkey and dog BimL (~19 kDa), BimEL (~23 kDa), and BimS (~16 kDa). Also recognizes the six novel isoforms of human Bim, generated by alternative splicing and lacking the C-terminal hydrophobic region.

Réactivité croisée: Chien, Humain, Singe, Souris, Rat (Rattus)

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.1EU/μg purified protein (LAL test, Lonza).

Immunogène: Synthetic peptide corresponding to aa 20-40 of mouse BimL.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide and 25 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détail du antigène

Antigène: BimS, EL, L

Autre désignation: BimS/EL/L

Sujet: Bim belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family (BCL2, BCL2L1/BCL-X(L) and MCL1) and to act as an apoptotic activator, inducing apoptosis and anoikis. Several variants have been identified. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.